The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLIX.v

Jarisch-Herxheimer reaction

Publications

Miller WM, Gorini F, Botelho G, Moreira C, Barbosa AP, Pinto AR, Dias MF, Souza LM, Asensi MD, da Costa Nery JA

Jarisch-Herxheimer reaction among syphilis patients in Rio de Janeiro, Brazil.

International journal of STD & AIDS 2010 Dec;21;806-9 — 2010 Dec — 806-9

Yang CJ, Lee NY, Lin YH, Lee HC, Ko WC, Liao CH, Wu CH, Hsieh CY, Wu PY, Liu WC, Chang YC, Hung CC

Jarisch-Herxheimer reaction after penicillin therapy among patients with syphilis in the era of the hiv infection epidemic: incidence and risk factors.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2010 Oct 15;51;976-9 — 2010 Oct 15 — 976-9

See S, Scott EK, Levin MW

Penicillin-induced Jarisch-Herxheimer reaction.

The Annals of pharmacotherapy 2005 Dec;39;2128-30 — 2005 Dec — 2128-30