The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.b

Pneumonitis (ILD), acute and/or severe (may cause ARDS)

Publications

Uittenbogaart SB, Klemt-Kropp M

[Mesalazine and sulphasalazine for Crohn's disease: few indications, severe adverse reactions].

Nederlands tijdschrift voor geneeskunde 2011;155;A3842 — 2011 — A3842

Hamadeh MA, Atkinson J, Smith LJ

Sulfasalazine-induced pulmonary disease.

Chest 1992 Apr;101;1033-7 — 1992 Apr — 1033-7