The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Valvular heart disease and/or dysfunction
Publications
Valvular heart disease with the use of fenfluramine-phentermine.
Texas Heart Institute journal. 2011;38(5):581-3
Aortic and mitral fenfluramine-phentermine valvulopathy in 64 patients treated with anorectic agents.
Archives of pathology & laboratory medicine. 2001;125(12):1555-61
Aminorex to fen/phen: an epidemic foretold.
Circulation. 1999;99(1):156-61
Valvular heart disease associated with fenfluramine-phentermine.
The New England journal of medicine. 1997;337(24):1772; author reply 1775
Further cases of valvular heart disease associated with fenfluramine-phentermine.
The New England journal of medicine. 1997;337(9):635
Valvular heart disease associated with fenfluramine-phentermine.
The New England journal of medicine. 1997;337(9):581-8