The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XII.l

Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

Publications

Harel Y, Scott WA, Szeinberg A, Barzilay Z

Pentamidine-induced torsades de pointes.

The Pediatric infectious disease journal 1993 Aug;12;692-4 — 1993 Aug — 692-4

Farquhar Zanetti LA, Oliphant CM

Pentamidine-induced torsades de pointes.

The Annals of pharmacotherapy 1994 Feb;28;282-3 — 1994 Feb — 282-3

Bibler MR, Chou TC, Toltzis RJ, Wade PA

Recurrent ventricular tachycardia due to pentamidine-induced cardiotoxicity.

Chest 1988 Dec;94;1303-6 — 1988 Dec — 1303-6

Glikson M, Dresner-Feigin R, Pollack A, Wolf D, Galun E, Tur-Kaspa R

Pentamidine-induced cardiotoxicity.

Israel journal of medical sciences 1990 Oct;26;588-9 — 1990 Oct — 588-9

Cortese LM, Gasser RA, Bjornson DC, Dacey MJ, Oster CN

Prolonged recurrence of pentamidine-induced torsades de pointes.

The Annals of pharmacotherapy 1992 Nov;26;1365-9 — 1992 Nov — 1365-9