The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Pulmonary edema, noncardiogenic (NCPE)
Publications
OKT3 (muromonab-CD3) associated hepatitis in a kidney transplant recipient.
Transplantation 2002 Jun 27;73;1957-9 — 2002 Jun 27 — 1957-9
Increased risk of pulmonary edema in diabetic patients undergoing preemptive pancreas transplantation with OKT3 induction.
Transplantation proceedings 1995 Dec;27;3016-7 — 1995 Dec — 3016-7
Cardiopulmonary effects of OKT3: determinants of hypotension, pulmonary edema, and cardiac dysfunction.
Transplantation proceedings 1993 Apr;25;21-4 — 1993 Apr — 21-4
General aspects of cytokine-release syndrome: timing and incidence of symptoms.
Transplantation proceedings 1993 Apr;25;16-20 — 1993 Apr — 16-20
A retrospective analysis of the effect of indomethacin on adverse reactions to orthoclone OKT3 in the therapy of acute renal allograft rejection.
American journal of kidney diseases : the official journal of the National Kidney Foundation 1994 Sep;24;486-90 — 1994 Sep — 486-90
OKT3 and pulmonary capillary permeability.
British medical journal (Clinical research ed.) 1987 Oct 31;295;1099-100 — 1987 Oct 31 — 1099-100
Acute pulmonary insufficiency due to OKT3 therapy.
Transplantation proceedings 1990 Aug;22;1779-81 — 1990 Aug — 1779-81