The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Rebound pulmonary arterial hypertension
Publications
Rebound pulmonary hypertension after inhalation of nitric oxide.
The Annals of thoracic surgery 1996 Dec;62;1759-64 — 1996 Dec — 1759-64
Life-threatening effects of discontinuing inhaled nitric oxide in severe respiratory failure.
American journal of respiratory and critical care medicine 1996 Jun;153;1985-7 — 1996 Jun — 1985-7