The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLI.a

Pulmonary edema, noncardiogenic (NCPE)

Mainly described in the context of poisoning or overdose

Publications

Ju G, Chen L, Wang R, Zhang L, Liu Z, Chen S

A disproportionality analysis of nifedipine in the overall population and in pregnant women using the FDA Adverse Event Reporting System (FAERS) database.

Medicine 2025 Oct 31;104;e45113 — 2025 Oct 31

Zhong Z, Liu M, Zhong Q, Zhou M, Di X

Drug-induced pulmonary edema: a real-world pharmacovigilance study using the FDA Adverse Event Reporting System (FAERS).

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2025;58;e14566 — 2025

Khattab NW, Razzouk R, Tanios B, Nahouli L, Bou Khalil P, El Khoury N

Pulmonary Edema Following Nifedipine Use in Pregnancy: A Case Report.

Cureus 2024 Sep;16;e68467 — 2024 Sep

Spiesser-Robelet L, Martin B, Carceller AM, Bussières JF, Touzin K, Audibert F, Lachance C, Ferreira E

[Adverse effects and hemodynamic effects of nifedipine as a tocolytic].

Journal de gynecologie, obstetrique et biologie de la reproduction 2015 Sep;44;614-20 — 2015 Sep — 614-20

Xiao C, Gangal M, Abenhaim HA

Effect of magnesium sulfate and nifedipine on the risk of developing pulmonary edema in preterm births.

Journal of perinatal medicine 2014 Sep;42;585-9 — 2014 Sep — 585-9

Kutuk MS, Ozgun MT, Uludag S, Dolanbay M, Yildirim A

Acute pulmonary failure due to pulmonary edema during tocolytic therapy with nifedipine.

Archives of gynecology and obstetrics 2013 Oct;288;953-4 — 2013 Oct — 953-4

Abbas OM, Nassar AH, Kanj NA, Usta IM

Acute pulmonary edema during tocolytic therapy with nifedipine.

American journal of obstetrics and gynecology 2006 Oct;195;e3-4 — 2006 Oct — e3-4

Gillmer DJ, Kark P

Pulmonary oedema precipitated by nifedipine.

British medical journal 1980 Jun 14;280;1420-1 — 1980 Jun 14 — 1420-1

Batra AK, Segall PH, Ahmed T

Pulmonary edema with nifedipine in primary pulmonary hypertension.

Respiration; international review of thoracic diseases 1985;47;161-3 — 1985 — 161-3

Herrington DM, Insley BM, Weinmann GG

Nifedipine overdose.

The American journal of medicine 1986 Aug;81;344-6 — 1986 Aug — 344-6

Prigogine T, Waterlot Y, Gottignies P, Verhoeven A, Decroly P

Acute nonhemodynamic pulmonary edema with nifedipine in primary pulmonary hypertension.

Chest 1991 Aug;100;563-4 — 1991 Aug — 563-4