The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
ARDS - Acute lung injury
This complications likely appears to be related to the dose or Ara-C (PMID 25689584)
Publications
Cytarabine-induced lung injury: case report.
Anti-cancer drugs 2005 Aug;16;743-5 — 2005 Aug — 743-5
Ara-C lung: noncardiogenic pulmonary edema complicating cytosine arabinoside therapy of leukemia.
The American journal of medicine 1981 Feb;70;256-61 — 1981 Feb — 256-61
Fatal pulmonary failure complicating high-dose cytosine arabinoside therapy in acute leukemia.
Cancer 1990 Mar 01;65;1079-84 — 1990 Mar 01 — 1079-84