The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.c

Capillary leak syndrome (CLS)

Publications

Mackie FE, Umetsu D, Salvatierra O, Sarwal MM

Pulmonary capillary leak syndrome with intravenous cyclosporin A in pediatric renal transplantation.

Pediatric transplantation. 2000;4(1):35-8

Hussein MM, Mooij JM, el Tayeb AM

Pulmonary capillary leak syndrome associated with the use of intravenous cyclosporin.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 1996;11(11):2342-3

Blaauw AA, Leunissen KM, Cheriex EC, Wolters J, Kootstra G, Van Hooff JP

Disappearance of pulmonary capillary leak syndrome when intravenous cyclosporine is replaced by oral cyclosporine.

Transplantation. 1987;43(5):758-9