The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LI.d

Myocarditis (can be fulminant)

Publications

Fenoglio JJ, McAllister HA, Mullick FG

Drug related myocarditis. I. Hypersensitivity myocarditis.

Human pathology 1981 Oct;12;900-7 — 1981 Oct — 900-7

Seeverens H, de Bruin CD, Jordans JG

Myocarditis and methyldopa.

Acta medica Scandinavica 1982 May;211;233-5 — 1982 May — 233-5

Bezahler GH

Fatal methyldopa-associated granulomatous hepatitis and myocarditis.

The American journal of the medical sciences 1982 Jan-Feb;283;41-5 — 1982 Jan-Feb — 41-5

Mullick FG, McAllister HA

Myocarditis associated with methyldopa therapy.

JAMA 1977 Apr 18;237;1699-701 — 1977 Apr 18 — 1699-701