The Drug-Induced Respiratory Disease Website and App

Hemotherapy (transfusion/infusion of whole blood, red cells, platelets, or blood products)

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLVI.n

Crystal pulmonary embolism

Publications

Van Ness M, Jensen H, Adamson GN, Kysar PE, Holland P

Neutrophils contain cholesterol crystals in transfusion-related acute lung injury (TRALI).

American journal of clinical pathology 2013 Aug;140;170-6 — 2013 Aug — 170-6

Jensen HM, Galante JM, Kysar PE, Tolstikov VV, Reddy KJ, Holland PV

TRALI is due to pulmonary venule damage from leucocytes with cholesterol crystal formation.

Vox sanguinis 2010 Feb;98;130-7 — 2010 Feb — 130-7