The Drug-Induced Respiratory Disease Website and App

Status post-hematopoietic stem cell (HSCT) or bone marrow transplantation (BMT)

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IV.c

Obliterative bronchiolitis (a pattern consistent with) (see also IVn, XVx)

Publications

Solh M, Arat M, Cao Q, Majhail NS, Weisdorf D

Late-onset noninfectious pulmonary complications in adult allogeneic hematopoietic cell transplant recipients.

Transplantation. 2011;91(7):798-803

Afessa B, Litzow MR, Tefferi A

Bronchiolitis obliterans and other late onset non-infectious pulmonary complications in hematopoietic stem cell transplantation.

Bone marrow transplantation. 2001;28(5):425-34

Worthy SA, Flint JD, Müller NL

Pulmonary complications after bone marrow transplantation: high-resolution CT and pathologic findings.

Radiographics : a review publication of the Radiological Society of North America, Inc. 1997;17(6):1359-71

Lentz D, Bergin CJ, Berry GJ, Stoehr C, Theodore J

Diagnosis of bronchiolitis obliterans in heart-lung transplantation patients: importance of bronchial dilatation on CT.

AJR. American journal of roentgenology. 1992;159(3):463-7