The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Alveolar hemorrhage (AH), diffuse AH (DAH)
Publications
Keklik F, Alrawi EB, Cao Q, Bejanyan N, Rashidi A, Lazaryan A, Arndt P, Dincer EH, Bachanova V, Warlick ED, MacMillan ML, Arora M, Miller J, Brunstein CG, Weisdorf DJ, Ustun C
Diffuse alveolar hemorrhage is most often fatal and is affected by graft source, conditioning regimen toxicity, and engraftment kinetics.
Haematologica. 2018;103(12):2109-2115
Late-onset noninfectious pulmonary complications in adult allogeneic hematopoietic cell transplant recipients.
Transplantation. 2011;91(7):798-803
Gupta S, Jain A, Warneke CL, Gupta A, Shannon VR, Morice RC, Onn A, Jimenez CA, Bashoura L, Giralt SA, Dickey BF, Eapen GA
Outcome of alveolar hemorrhage in hematopoietic stem cell transplant recipients.
Bone marrow transplantation. 2007;40(1):71-8
Diffuse alveolar hemorrhage after allogeneic hematopoietic stem-cell transplantation: treatment with recombinant factor VIIa.
Chest. 2003;124(6):2400-3
Pulmonary complications after bone marrow transplantation: high-resolution CT and pathologic findings.
Radiographics : a review publication of the Radiological Society of North America, Inc. 1997;17(6):1359-71
Diffuse alveolar haemorrhage associated with microangiopathy after allogeneic bone marrow transplantation.
Bone marrow transplantation. 1995;15(6):863-7