The Drug-Induced Respiratory Disease Website and App

Status post-hematopoietic stem cell (HSCT) or bone marrow transplantation (BMT)

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLII.a

Alveolar hemorrhage (AH), diffuse AH (DAH)

Publications

Keklik F, Alrawi EB, Cao Q, Bejanyan N, Rashidi A, Lazaryan A, Arndt P, Dincer EH, Bachanova V, Warlick ED, MacMillan ML, Arora M, Miller J, Brunstein CG, Weisdorf DJ, Ustun C

Diffuse alveolar hemorrhage is most often fatal and is affected by graft source, conditioning regimen toxicity, and engraftment kinetics.

Haematologica 2018 Dec;103;2109-2115 — 2018 Dec — 2109-2115

Solh M, Arat M, Cao Q, Majhail NS, Weisdorf D

Late-onset noninfectious pulmonary complications in adult allogeneic hematopoietic cell transplant recipients.

Transplantation 2011 Apr 15;91;798-803 — 2011 Apr 15 — 798-803

Gupta S, Jain A, Warneke CL, Gupta A, Shannon VR, Morice RC, Onn A, Jimenez CA, Bashoura L, Giralt SA, Dickey BF, Eapen GA

Outcome of alveolar hemorrhage in hematopoietic stem cell transplant recipients.

Bone marrow transplantation 2007 Jul;40;71-8 — 2007 Jul — 71-8

Pastores SM, Papadopoulos E, Voigt L, Halpern NA

Diffuse alveolar hemorrhage after allogeneic hematopoietic stem-cell transplantation: treatment with recombinant factor VIIa.

Chest 2003 Dec;124;2400-3 — 2003 Dec — 2400-3

Worthy SA, Flint JD, Müller NL

Pulmonary complications after bone marrow transplantation: high-resolution CT and pathologic findings.

Radiographics : a review publication of the Radiological Society of North America, Inc 1997 Nov-Dec;17;1359-71 — 1997 Nov-Dec — 1359-71

Srivastava A, Gottlieb D, Bradstock KF

Diffuse alveolar haemorrhage associated with microangiopathy after allogeneic bone marrow transplantation.

Bone marrow transplantation 1995 Jun;15;863-7 — 1995 Jun — 863-7