The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Acute pulmonary vasoconstriction and PHT
Publications
A case of catastrophic pulmonary vasoconstriction after protamine administration in cardiac surgery: role of intraoperative transesophageal echocardiography.
Journal of cardiothoracic and vascular anesthesia 2008 Oct;22;727-31 — 2008 Oct — 727-31
The use of nitric oxide for managing catastrophic pulmonary vasoconstriction arising from protamine administration.
Anesthesia and analgesia 1999 Mar;88;505-7 — 1999 Mar — 505-7
Catastrophic pulmonary vasoconstriction associated with protamine reversal of heparin.
Anesthesiology 1983 Nov;59;470-3 — 1983 Nov — 470-3
Protamine reactions, explosive mediator release, and pulmonary vasoconstriction.
Anesthesiology 1990 Sep;73;373-5 — 1990 Sep — 373-5