The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Pulmonary arterial hypertension
Most reports were published in a quite distant past. There is no strong recent evidence
Publications
Pulmonary hypertension, systemic lupus erythematosus, and the contraceptive pill: another report.
Annals of the rheumatic diseases. 1987;46(2):159-61
Editorial: Pulmonary hypertension and oral contraceptive usage.
Chest. 1976;69(4):451-3
Pulmonary hypertension in patients using oral contraceptives. A report of six cases.
Chest. 1976;69(2):143-7