The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a

Pneumonitis (ILD), acute and/or severe (may produce the ARDS pattern)

Publications

Watzal V, Godbersen GM, Weidenauer A, Willeit M, Popper V, Treiber M, Preiss M, Ivkic D, Rabl U, Fugger G, Frey R, Kraus C, Rujescu D, Bartova L

Case report: Interstitial pneumonitis after initiation of lamotrigine.

Frontiers in psychiatry. 2023;14:1203497

Fernandes C, Bungay P, O'Driscoll BR, Herrick AL

Mixed connective tissue disease presenting with pneumonitis and pneumatosis intestinalis.

Arthritis and rheumatism. 2000;43(3):704-7