The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

VI.k

Eosinophilic pulmonary vasculitis

Publications

Tazelaar HD, Myers JL, Strickler JG, Colby TV, Duffy J

Tryptophan-induced lung disease: an immunophenotypic, immunofluorescent, and electron microscopic study.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 1993;6(1):56-60

Banner AS, Borochovitz D

Acute respiratory failure caused by pulmonary vasculitis after L-tryptophan ingestion.

The American review of respiratory disease. 1991;143(3):661-4

Strumpf IJ, Drucker RD, Anders KH, Cohen S, Fajolu O

Acute eosinophilic pulmonary disease associated with the ingestion of L-tryptophan-containing products.

Chest. 1991;99(1):8-13