The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.f

Anaphylaxis-Anaphylactoid reaction (can be fatal)

Publications

Spiegel RJ, Echelberger CK, Poplack DG

Delayed allergic reactions following intramuscular L-asparaginase.

Medical and pediatric oncology. 1980;8(2):123-5

Shapiro S, Slone D, Lewis GP, Jick H

Fatal drug reactions among medical inpatients.

JAMA. 1971;216(3):467-72

Haskell CM, Canellos GP, Leventhal BG, Carbone PP, Block JB, Serpick AA, Selawry OS

L-asparaginase: therapeutic and toxic effects in patients with neoplastic disease.

The New England journal of medicine. 1969;281(19):1028-34

Fabry U, Körholz D, Jürgens H, Göbel U, Wahn V

Anaphylaxis to L-asparaginase during treatment for acute lymphoblastic leukemia in children--evidence of a complement-mediated mechanism.

Pediatric research. 1985;19(4):400-8