The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLV.m

Pleuropericarditis - Pleuropericardial effusion (ANA unknown or negative)

Publications

Günther J, Lode H, Raffenberg M, Schaberg T

Development of pleural and pericardial effusions during itraconazole therapy of pulmonary aspergillosis.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 1993 Sep;12;723-4 — 1993 Sep — 723-4