The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a

Pneumonitis (ILD)

Publications

Migita K, Umeno T, Miyagawa K, Izumi Y, Sasaki E, Kakugawa T, Ito M, Kinoshita A, Miyashita T

Development of interstitial pneumonia in a patient with rheumatoid arthritis induced by isoniazid for tuberculosis chemoprophylaxis.

Rheumatology international 2012 May;32;1375-7 — 2012 May — 1375-7

Endo T, Saito T, Nakayama M, Ohse H, Watanabe S, Tamai S, Hasegawa S

[A case of isoniazid-induced pneumonitis].

Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 1998 Jan;36;100-5 — 1998 Jan — 100-5

Salomaa ER, Ruokonen EL, Tevola K, Tala E

Pulmonary infiltrates and fever induced by isoniazid.

Postgraduate medical journal 1990 Aug;66;647-9 — 1990 Aug — 647-9