The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.c

Capillary leak syndrome (CLS)

Publications

Lagan J, Naish JH, Fortune C, Campbell C, Chow S, Pillai M, Bradley J, Francis L, Clark D, Macnab A, Nucifora G, Dobson R, Schelbert EB, Schmitt M, Hawkins R, Miller CA

Acute and Chronic Cardiopulmonary Effects of High Dose Interleukin-2 Therapy: An Observational Magnetic Resonance Imaging Study.

Diagnostics (Basel, Switzerland). 2022;12(6)

Lotze MT, Matory YL, Rayner AA, Ettinghausen SE, Vetto JT, Seipp CA, Rosenberg SA

Clinical effects and toxicity of interleukin-2 in patients with cancer.

Cancer. 1986;58(12):2764-72

Glauser FL, DeBlois G, Bechard D, Fowler AA, Merchant R, Fairman RP

Cardiopulmonary toxicity of adoptive immunotherapy.

The American journal of the medical sciences. 1988;296(6):406-12

Lee RE, Lotze MT, Skibber JM, Tucker E, Bonow RO, Ognibene FP, Carrasquillo JA, Shelhamer JH, Parrillo JE, Rosenberg SA

Cardiorespiratory effects of immunotherapy with interleukin-2.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 1989;7(1):7-20

van Haelst Pisani C, Kovach JS, Kita H, Leiferman KM, Gleich GJ, Silver JE, Dennin R, Abrams JS

Administration of interleukin-2 (IL-2) results in increased plasma concentrations of IL-5 and eosinophilia in patients with cancer.

Blood. 1991;78(6):1538-44

Morassut S, Balestreri L, Galligioni E, Coran F, Sacco C

[Radiologic characteristics of the thorax during therapy with interleukin-2].

La Radiologia medica. 1992;84(4):368-71