The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.r

Fluid retention

Publications

Lotze MT, Matory YL, Rayner AA, Ettinghausen SE, Vetto JT, Seipp CA, Rosenberg SA

Clinical effects and toxicity of interleukin-2 in patients with cancer.

Cancer 1986 Dec 15;58;2764-72 — 1986 Dec 15 — 2764-72

Morassut S, Balestreri L, Galligioni E, Coran F, Sacco C

[Radiologic characteristics of the thorax during therapy with interleukin-2].

La Radiologia medica 1992 Oct;84;368-71 — 1992 Oct — 368-71