The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

VI.e

Hemothorax - Serosanguineous pleural effusion

Publications

Boulé S, Marquié C, Vanesson-Bricout C, Kouakam C, Brigadeau F, Guédon-Moreau L, Acheré C, Goéminne-Boulé C, Lacroix D, Klug D, Kacet S

Clopidogrel increases bleeding complications in patients undergoing heart rhythm device procedures.

Pacing and clinical electrophysiology : PACE 2012 May;35;605-11 — 2012 May — 605-11

Borderías Clau L, Garrapiz López J, Caballero G

[Pulmonary haemorrhage and haemothorax after massive ingestion of clopidogrel as a suicide attempt].

Archivos de bronconeumologia 2009 Nov;45;570-1 — 2009 Nov — 570-1

Haro Estarriol M, Alvarez Castillo LA, Baldó Padró X, Palou Rispau A, Rubio Garay M, Rubio Goday M

[Bilateral hemothorax secondary to combined antiplatelet therapy with clopidogrel and acetylsalicylic acid].

Archivos de bronconeumologia 2006 Jun;42;307-9 — 2006 Jun — 307-9

Shennib H, Endo M, Benhameid O

A feasibility study of the safety and efficacy of a combined clopidogrel and aspirin regimen following off-pump coronary artery bypass grafting.

The heart surgery forum 2003;6;288-91 — 2003 — 288-91