The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LI.c

Pericardial effusion (w/wo tamponade)

Publications

Zeitjian V, Mehdizadeh A

ANA-Negative Hydralazine-Induced Pericardial Effusion.

Case reports in medicine 2017;2017;3521541 — 2017 — 3521541

DUSTAN HP, TAYLOR RD, CORCORAN AC

Rheumatic and febrile syndrome during prolonged hydralazine treatment.

Journal of the American Medical Association 1954 Jan 02;154;23-9 — 1954 Jan 02 — 23-9

Siddiqui MA, Khan IA

Isoniazid-induced lupus erythematosus presenting with cardiac tamponade.

American journal of therapeutics 2002 Mar-Apr;9;163-5 — 2002 Mar-Apr — 163-5

Carey RM, Coleman M, Feder A

Pericardial tamponade: a major presenting manifestation of hydralazine-induced lupus syndrome.

The American journal of medicine 1973 Jan;54;84-7 — 1973 Jan — 84-7