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The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IX.a

Diaphragm/inspiratory muscle weakness/paralysis (w/wo ARF)

Publications

Ntelios D, Kargakis M, Topalis T, Drouzas A, Potolidis E

Acute respiratory failure due to Nicotiana glauca ingestion.

Hippokratia. 2013;17(2):183-4

West PL, Horowitz BZ, Montanaro MT, Lindsay JN

Poison hemlock-induced respiratory failure in a toddler.

Pediatric emergency care. 2009;25(11):761-3

Elinav E, Chajek-Shaul T

Licorice consumption causing severe hypokalemic paralysis.

Mayo Clinic proceedings. 2003;78(6):767-8