The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.g

Pulmonary fibrosis

Publications

Mack U, Schmidt K, Heine M

[Fatal diffuse alveolar damage after gold medication].

Pneumologie (Stuttgart, Germany). 1994;48(5):405-8

Music E, Tomsic M, Logar D

[Gold salt alveolitis in 3 patients with rheumatoid arthritis].

Pneumologie (Stuttgart, Germany). 1995;49(6):367-72

Levinson ML, Lynch JP 3rd, Bower JS

Reversal of progressive, life-threatening gold hypersensitivity pneumonitis by corticosteroids.

The American journal of medicine. 1981;71(5):908-12

Chatzigiannis I, Schmidt KL, Stambolis C

[Fatal pulmonary fibrosis caused by gold therapy?].

Zeitschrift fur Rheumatologie. 1984;43(2):49-58

Geddes DM, Brostoff J

Pulmonary fibrosis associated with hypersensitivity to gold salts.

British medical journal. 1976;1(6023):1444