The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.g

Pulmonary fibrosis

Publications

Mack U, Schmidt K, Heine M

[Fatal diffuse alveolar damage after gold medication].

Pneumologie (Stuttgart, Germany) 1994 May;48;405-8 — 1994 May — 405-8

Music E, Tomsic M, Logar D

[Gold salt alveolitis in 3 patients with rheumatoid arthritis].

Pneumologie (Stuttgart, Germany) 1995 Jun;49;367-72 — 1995 Jun — 367-72

Levinson ML, Lynch JP, Bower JS

Reversal of progressive, life-threatening gold hypersensitivity pneumonitis by corticosteroids.

The American journal of medicine 1981 Nov;71;908-12 — 1981 Nov — 908-12

Chatzigiannis I, Schmidt KL, Stambolis C

[Fatal pulmonary fibrosis caused by gold therapy?].

Zeitschrift fur Rheumatologie 1984 Mar-Apr;43;49-58 — 1984 Mar-Apr — 49-58

Geddes DM, Brostoff J

Pulmonary fibrosis associated with hypersensitivity to gold salts.

British medical journal 1976 Jun 12;1;1444 — 1976 Jun 12 — 1444