The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XII.a

Left or biventricular dysfunction/failure

Publications

Mishra T, Shokr M, Ahmed A, Afonso L

Acute reversible left ventricular systolic dysfunction associated with 5-fluorouracil therapy: a rare and increasingly recognised cardiotoxicity of a commonly used drug.

BMJ case reports. 2019;12(9)

Fakhri Y, Dalsgaard M, Nielsen D, Lav Madsen P

5-Fluorouracil-induced acute reversible heart failure not explained by coronary spasms, myocarditis or takotsubo: lessons from MRI.

BMJ case reports. 2016;2016

Iskandar MZ, Quasem W, El-Omar M

5-Fluorouracil cardiotoxicity: reversible left ventricular systolic dysfunction with early detection.

BMJ case reports. 2015;2015

Dechant C, Baur M, Böck R, Czejka M, Podczeck-Schweighofer A, Dittrich C, Christ G

Acute Reversible Heart Failure Caused by Coronary Vasoconstriction due to Continuous 5-Fluorouracil Combination Chemotherapy.

Case reports in oncology. 2012;5(2):296-301

Timour Q, Lombard-Bohas C, Slim R, Barel C, Bui-Xuan B, Tabib A, Bricca G, Malonne H, Vial T, Iordescu D, Descotes J

[Cardiotoxicity of 5-fluorouracil: report of 6 cases].

Therapie. 2002;57(3):302-6