The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.g

Pulmonary fibrosis

The fibrosis caused by nitrosoureas has the reputation for being severe, progressive and fatal

Publications

Sordillo EM, Sordillo PP, Stover D, Magill GB

Chlorozotocin (DCNU)--induced pulmonary toxicity.

Cancer clinical trials 1981;4;397-9 — 1981 — 397-9

Ahlgren JD, Smith FP, Kerwin DM, Sikic BI, Weiner JH, Schein PS

Pulmonary disease as a complication of chlorozotocin chemotherapy.

Cancer treatment reports 1981 Mar-Apr;65;223-9 — 1981 Mar-Apr — 223-9

Goedert JJ, Smith FP, Tsou E, Weiss RB

Combination chemotherapy pneumonitis: a case report of possible synergistic toxicity.

Medical and pediatric oncology 1983;11;116-8 — 1983 — 116-8