The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

VI.e

Fat/oil embolism - The FES embolism syndrome

Publications

Russell M, Storck A, Ainslie M

Acute respiratory distress following intravenous injection of an oil-steroid solution.

Canadian respiratory journal. 2011;18(4):e59-61

Chondrogiannis KD, Siontis GC, Koulouras VP, Lekka ME, Nakos G

Acute lung injury probably associated with infusion of propofol emulsion.

Anaesthesia. 2007;62(8):835-7

Reedy JS, Kuhlman JE, Voytovich M

Microvascular pulmonary emboli secondary to precipitated crystals in a patient receiving total parenteral nutrition: a case report and description of the high-resolution CT findings.

Chest. 1999;115(3):892-5

Kitchell CC, Balogh K

Pulmonary lipid emboli in association with long-term hyperalimentation.

Human pathology. 1986;17(1):83-5

Puntis JW, Rushton DI

Pulmonary intravascular lipid in neonatal necropsy specimens.

Archives of disease in childhood. 1991;66(1 Spec No):26-8