The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.b

Pneumonitis (interstitial lung disease/ILD)

Publications

Shafqat H, Olszewski AJ

Chlorambucil-induced acute interstitial pneumonitis.

Case reports in hematology. 2014;2014:575417

Khong HT, McCarthy J

Chlorambucil-induced pulmonary disease: a case report and review of the literature.

Annals of hematology. 1998;77(1-2):85-7

Crestani B, Jaccard A, Israël-Biet D, Couderc LJ, Frija J, Clauvel JP

Chlorambucil-associated pneumonitis.

Chest. 1994;105(2):634-6

MacMahon H, Bekerman C

The diagnostic significance of gallium lung uptake in patients with normal chest radiographs.

Radiology. 1978;127(1):189-93