The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Pulmonary edema, noncardiogenic (NCPE)
Only overdoses of tricyclic antidepressants do cause NCPE, ALI or ARDS
Publications
Dibenzepin overdose causing pulmonary edema.
The Annals of pharmacotherapy 1996 Jul-Aug;30;789-90 — 1996 Jul-Aug — 789-90
Adult respiratory distress syndrome from overdose of tricyclic antidepressants.
Radiology 1989 Mar;170;667-70 — 1989 Mar — 667-70