The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.b

ARDS - Acute lung injury

Publications

Lekka ME, Liokatis S, Nathanail C, Galani V, Nakos G

The impact of intravenous fat emulsion administration in acute lung injury.

American journal of respiratory and critical care medicine. 2004;169(5):638-44

Reedy JS, Kuhlman JE, Voytovich M

Microvascular pulmonary emboli secondary to precipitated crystals in a patient receiving total parenteral nutrition: a case report and description of the high-resolution CT findings.

Chest. 1999;115(3):892-5

Schöffski P, Freund M, Wunder R, Petersen D, Köhne CH, Hecker H, Schubert U, Ganser A

Safety and toxicity of amphotericin B in glucose 5% or intralipid 20% in neutropenic patients with pneumonia or fever of unknown origin: randomised study.

BMJ (Clinical research ed.). 1998;317(7155):379-84

Wesson DE, Rich RH, Zlotkin SH, Pencharz PB

Fat overload syndrome causing respiratory insufficiency.

Journal of pediatric surgery. 1984;19(6):777-8