The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Severe or catastrophic bronchospasm or asthma attack (can be fatal)
Publications
Catastrophic Bronchial Spasm Due to a Severe Anaphylactic Reaction to Protamine.
The Korean journal of thoracic and cardiovascular surgery 2016 Dec;49;472-474 — 2016 Dec — 472-474
The successful management of severe protamine-induced pulmonary hypertension using inhaled prostacyclin.
Anesthesia and analgesia 2010 Feb 01;110;365-9 — 2010 Feb 01 — 365-9
[Complications caused by protamine. 1: Pharmacology and pathophysiology].
Der Anaesthesist 1991 Jul;40;365-74 — 1991 Jul — 365-74