The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Neutropenia, agranulocytosis (w/wo infection/sepsis)
Publications
Ishimaru N, Ohnishi H, Nishiuma T, Doukuni R, Umezawa K, Oozone S, Kuramoto E, Yoshimura S, Kinami S
Antithyroid drug-induced agranulocytosis complicated by pneumococcal sepsis and upper airway obstruction.
Internal medicine (Tokyo, Japan) 2013;52;2355-9 — 2013 — 2355-9
[Pulmonary aspergillosis due to methimazole-induced neutropenia: a case report].
Revista peruana de medicina experimental y salud publica 2012 Jun;29;255-8 — 2012 Jun — 255-8
Delayed anithyroid drug-induced agranulocytosis.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2012 Jul-Aug;18;e69-72 — 2012 Jul-Aug — e69-72