The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

VI.a

Pulmonary embolism - Venous thrombosis/thromboembolism

Publications

Gallerani M, Imberti D, Mari E, Marra A, Manfredini R

Risperidone and pulmonary embolism: a harmful association? Case series and review of the literature.

Acta neuropsychiatrica. 2012;24(6):361-8

Borras L, Eytan A, de Timary P, Constant EL, Huguelet P, Hermans C

Pulmonary thromboembolism associated with olanzapine and risperidone.

The Journal of emergency medicine. 2008;35(2):159-61

Kamijo Y, Soma K, Nagai T, Kurihara K, Ohwada T

Acute massive pulmonary thromboembolism associated with risperidone and conventional phenothiazines.

Circulation journal : official journal of the Japanese Circulation Society. 2003;67(1):46-8