The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XII.g

Cardiomyopathy (acute, subacute, chronic)

Review on PMID 29858838

Publications

Chatre C, Roubille F, Vernhet H, Jorgensen C, Pers YM

Cardiac Complications Attributed to Chloroquine and Hydroxychloroquine: A Systematic Review of the Literature.

Drug safety 2018 10;41;919-931 — 2018 10 — 919-931

Saussine A, Loriot MA, Picard C, Lecerf V, Landry J, Scheer I, Voicu S, Leenhardt A, Ducrocq G, Maubec E, Crickx B

[Chloroquine cardiotoxicity in long-term lupus therapy in two patients].

Annales de dermatologie et de venereologie 2009 Jun-Jul;136;530-5 — 2009 Jun-Jul — 530-5

Veinot JP, Mai KT, Zarychanski R

Chloroquine related cardiac toxicity.

The Journal of rheumatology 1998 Jun;25;1221-5 — 1998 Jun — 1221-5