The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LI.g

Cardiomyopathy (acute, subacute, chronic)

Review on PMID 29858838

Publications

Brown B, Joseph C, Talanki V, Budzikowski AS, McFarlane SI, John S

Severe Hypertrophic Cardiomyopathy Associated With Hydroxychloroquine in a Young Woman With Systemic Lupus Erythematosus: A Case Report and Review of the Literature.

Cureus 2024 May;16;e61452 — 2024 May

Malhotra A, Pathak MA, Dalia T, Vidic A

Endomyocardial biopsy-proven hydroxychloroquine-induced cardiomyopathy in a patient with rheumatoid arthritis.

BMJ case reports 2023 Apr 13;16; — 2023 Apr 13

Chang A, Stolin G, Fan J, Larreta BR, Fishbein GA, Wallace WD, Baas AS, Cruz D, Wang J

Hypertrophic cardiomyopathy in a lupus patient: a case of hydroxychloroquine cardiotoxicity.

ESC heart failure 2019 Sep 07;; — 2019 Sep 07

Chatre C, Roubille F, Vernhet H, Jorgensen C, Pers YM

Cardiac Complications Attributed to Chloroquine and Hydroxychloroquine: A Systematic Review of the Literature.

Drug safety 2018 10;41;919-931 — 2018 10 — 919-931

Zerbib Y, Guillaumont MP, Touati G, Duhaut P, Schmidt J

[Early cardiotoxicity of Hydroxychloroquine].

La Revue de medecine interne 2016 Mar;37;209-11 — 2016 Mar — 209-11

Tönnesmann E, Kandolf R, Lewalter T

Chloroquine cardiomyopathy - a review of the literature.

Immunopharmacology and immunotoxicology 2013 Jun;35;434-42 — 2013 Jun — 434-42

Abbasi S, Tarter L, Farzaneh-Far R, Farzaneh-Far A

Hydroxychloroquine: a treatable cause of cardiomyopathy.

Journal of the American College of Cardiology 2012 Aug 21;60;786 — 2012 Aug 21 — 786

Newton-Cheh C, Lin AE, Baggish AL, Wang H

Case records of the Massachusetts General Hospital. Case 11-2011. A 47-year-old man with systemic lupus erythematosus and heart failure.

The New England journal of medicine 2011 Apr 14;364;1450-60 — 2011 Apr 14 — 1450-60

Muthukrishnan P, Roukoz H, Grafton G, Jessurun J, Colvin-Adams M

Hydroxychloroquine-induced cardiomyopathy: a case report.

Circulation. Heart failure 2011 Mar;4;e7-8 — 2011 Mar — e7-8

Saussine A, Loriot MA, Picard C, Lecerf V, Landry J, Scheer I, Voicu S, Leenhardt A, Ducrocq G, Maubec E, Crickx B

[Chloroquine cardiotoxicity in long-term lupus therapy in two patients].

Annales de dermatologie et de venereologie 2009 Jun-Jul;136;530-5 — 2009 Jun-Jul — 530-5

Manohar VA, Moder KG, Edwards WD, Klarich K

Restrictive cardiomyopathy secondary to hydroxychloroquine therapy.

The Journal of rheumatology 2009 Feb;36;440-1 — 2009 Feb — 440-1

Soong TR, Barouch LA, Champion HC, Wigley FM, Halushka MK

New clinical and ultrastructural findings in hydroxychloroquine-induced cardiomyopathy--a report of 2 cases.

Human pathology 2007 Dec;38;1858-63 — 2007 Dec — 1858-63