The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Pulmonary fibrosis
Publications
Chlorambucil-induced acute interstitial pneumonitis.
Case reports in hematology 2014;2014;575417 — 2014 — 575417
Interstitial lung disease--an underdiagnosed side effect of chlorambucil?
Annals of hematology 1993 Dec;67;305-7 — 1993 Dec — 305-7
Fatal interstitial pneumonitis following high-dose intermittent chlorambucil therapy for chronic lymphocyte leukemia.
Cancer 1981 Jan 01;47;32-6 — 1981 Jan 01 — 32-6
[Alveolitis and lung fibrosis following therapy with chlorambucil].
Praxis und Klinik der Pneumologie 1984 Mar;38;108-11 — 1984 Mar — 108-11
Possible pulmonary effects of alkylating agents.
The New England journal of medicine 1972 Nov 30;287;1150-1 — 1972 Nov 30 — 1150-1
Chlorambucil induced pulmonary fibrosis: report of a case and review.
Virginia medical 1986 Nov;113;677-80 — 1986 Nov — 677-80
Chlorambucil lung toxicity.
Acta haematologica 1990;83;156-8 — 1990 — 156-8
Pulmonary disease with chlorambucil therapy.
Cancer 1978 Feb;41;455-9 — 1978 Feb — 455-9
Interstitial pneumonia and chlorambucil.
Chest 1979 Oct;76;471-3 — 1979 Oct — 471-3
Fatal intraalveolar and interstitial lung fibrosis in chlorambucil-treated chronic lymphocytic leukemia.
The Mount Sinai journal of medicine, New York 1977 Nov-Dec;44;847-51 — 1977 Nov-Dec — 847-51