The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

VIII.a

Angioedema (may cause UAO, asphyxia and death)

Publications

Venkateswararao S, Rajendiran G, Sundaram RS, Mounika G

Kounis syndrome secondary to intravenous cephalosporin administration.

Journal of pharmacology & pharmacotherapeutics. 2015;6(4):225-7

Du ZB, Zhu Y, Tan H, Guan DW, Wu X, Li RB, Gao WM, Mao RM, Zhu BL

[Twenty autopsy cases of anaphylactic shock induced by cephalosporins].

Fa yi xue za zhi. 2011;27(2):125-8

Romano A, Mondino C, Viola M, Montuschi P

Immediate allergic reactions to beta-lactams: diagnosis and therapy.

International journal of immunopathology and pharmacology. 2003;16(1):19-23