The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a

Pneumonitis (interstitial lung disease/ILD)

Publications

Steinfort CL, Wiggins J, Sheffield EA, Keal EE

Alveolitis associated with sulphamethoxypyridazine.

Thorax 1989 Apr;44;310-1 — 1989 Apr — 310-1

Porter JC, Friedland JS, Wojnarowska F, Ledingham JG

Alveolitis associated with sulphamethoxypyridazine.

Thorax 1989 Sep;44;766-7 — 1989 Sep — 766-7

Lenox-Smith I

Alveolitis associated with sulphamethoxypyridazine.

Thorax 1990 Feb;45;158 — 1990 Feb — 158