The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IV.a

Bronchospasm - Wheezing - Asthma

In the paper by Gernez et al. the reaction occured specifically with a generic carboplatin, not with the proprietary drug

Publications

Winkeljohn D, Polovich M

Carboplatin hypersensitivity reactions.

Clinical journal of oncology nursing 2006 Oct;10;595-8 — 2006 Oct — 595-8

Gernez Y, Barlesi F, Astoul P, Magnan A

[Hypersensitivity to carboplatin. An effect of generic drugs?].

Revue des maladies respiratoires 2006 Jun;23;269-72 — 2006 Jun — 269-72