The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Anaphylaxis-Anaphylactoid reaction (can be fatal)
Publications
Anaphylaxis and Cardiac Arrest Induced by Initial Intravenous Ceftriaxone: A Case Report.
The American journal of case reports 2026 Jan 15;27;e949917 — 2026 Jan 15
Basile RC, Rivera GG, Del Rio LA, de Bonis TC, do Amaral GP, Giangrecco E, Ferraz G, Yoshinari NH, Canola PA, Queiroz Neto A
Anaphylactoid reaction caused by sodium ceftriaxone in two horses experimentally infected by Borrelia burgdorferi.
BMC veterinary research 2015 Aug 12;11;197 — 2015 Aug 12 — 197
Fatal adverse effects of injected ceftriaxone sodium in China.
Pharmacoepidemiology and drug safety 2012 Nov;21;1197-201 — 2012 Nov — 1197-201