The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LI.h

Coronary artery disease (acute) - Myocardial ischemia/infarction

Publications

Sara JD, Kaur J, Khodadadi R, Rehman M, Lobo R, Chakrabarti S, Herrmann J, Lerman A, Grothey A

5-fluorouracil and cardiotoxicity: a review.

Therapeutic advances in medical oncology 2018;10;1758835918780140 — 2018 — 1758835918780140

Iskandar MZ, Quasem W, El-Omar M

5-Fluorouracil cardiotoxicity: reversible left ventricular systolic dysfunction with early detection.

BMJ case reports 2015 May 02;2015; — 2015 May 02

Killu A, Madhavan M, Prasad K, Prasad A

5-fluorouracil induced pericarditis.

BMJ case reports 2011 Apr 15;2011; — 2011 Apr 15

Tsibiribi P, Descotes J, Lombard-Bohas C, Barel C, Bui-Xuan B, Belkhiria M, Tabib A, Timour Q

Cardiotoxicity of 5-fluorouracil in 1350 patients with no prior history of heart disease.

Bulletin du cancer 2006 Mar 01;93;E27-30 — 2006 Mar 01 — E27-30

Timour Q, Lombard-Bohas C, Slim R, Barel C, Bui-Xuan B, Tabib A, Bricca G, Malonne H, Vial T, Iordescu D, Descotes J

[Cardiotoxicity of 5-fluorouracil: report of 6 cases].

Therapie 2002 May-Jun;57;302-6 — 2002 May-Jun — 302-6

Keefe DL, Roistacher N, Pierri MK

Clinical cardiotoxicity of 5-fluorouracil.

Journal of clinical pharmacology 1993 Nov;33;1060-70 — 1993 Nov — 1060-70

Millward MJ, Ganju V, Buck M

Cardiac arrest--a manifestation of 5-fluorouracil cardiotoxicity.

Australian and New Zealand journal of medicine 1988 Aug;18;693-5 — 1988 Aug — 693-5