The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XII.g

Coronary artery disease (acute) - Myocardial ischemia/infarction

Publications

Sara JD, Kaur J, Khodadadi R, Rehman M, Lobo R, Chakrabarti S, Herrmann J, Lerman A, Grothey A

5-fluorouracil and cardiotoxicity: a review.

Therapeutic advances in medical oncology. 2018;10:1758835918780140

Iskandar MZ, Quasem W, El-Omar M

5-Fluorouracil cardiotoxicity: reversible left ventricular systolic dysfunction with early detection.

BMJ case reports. 2015;2015

Killu A, Madhavan M, Prasad K, Prasad A

5-fluorouracil induced pericarditis.

BMJ case reports. 2011;2011

Tsibiribi P, Descotes J, Lombard-Bohas C, Barel C, Bui-Xuan B, Belkhiria M, Tabib A, Timour Q

Cardiotoxicity of 5-fluorouracil in 1350 patients with no prior history of heart disease.

Bulletin du cancer. 2006;93(3):E27-30

Timour Q, Lombard-Bohas C, Slim R, Barel C, Bui-Xuan B, Tabib A, Bricca G, Malonne H, Vial T, Iordescu D, Descotes J

[Cardiotoxicity of 5-fluorouracil: report of 6 cases].

Therapie. 2002;57(3):302-6

Keefe DL, Roistacher N, Pierri MK

Clinical cardiotoxicity of 5-fluorouracil.

Journal of clinical pharmacology. 1993;33(11):1060-70

Millward MJ, Ganju V, Buck M

Cardiac arrest--a manifestation of 5-fluorouracil cardiotoxicity.

Australian and New Zealand journal of medicine. 1988;18(5):693-5