The Drug-Induced Respiratory Disease Website and App

BCG therapy (topical instillations in the urinary bladder)

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.b

Pneumonitis (ILD), acute and/or severe (may cause ARDS)

Publications

Yoshioka F, Kato T, Shima Y, Hatano K, Kawashima A, Fukuhara S, Imamura R, Nonomura N

Drug-induced interstitial pneumonia after intravesical Bacillus Calmette-Guerin administration for bladder cancer with scleroderma.

IJU case reports 2023 Mar;6;133-136 — 2023 Mar — 133-136

Pommier JD, Ben Lasfar N, Van Grunderbeeck N, Burdet C, Laouénan C, Rioux C, Pierre-Audigier C, Meybeck A, Choudat L, Benchikh A, Nguyen S, Bouvet E, Yeni P, Yazdanpanah Y, Joly V

Complications following intravesical bacillus Calmette-Guerin treatment for bladder cancer: a case series of 22 patients.

Infectious diseases (London, England) 2015;47;725-31 — 2015 — 725-31

Caramori G, Artioli D, Ferrara G, Cazzuffi R, Pasquini C, Libanore M, Guardigni V, Guzzinati I, Contoli M, Rossi R, Rinaldi R, Contini C, Papi A

Severe pneumonia after intravesical BCG instillation in a patient with invasive bladder cancer: case report and literature review.

Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace 2013 Mar;79;44-8 — 2013 Mar — 44-8

Kaklamanos M, Hardavella G, Trigidou R, Dionellis G, Paissios N, Koulouris N, Goritsas C

Multi-organ failure with atypical liver granulomas following intravesical Bacillus Calmette-Guerin instillation.

World journal of hepatology 2011 Mar 27;3;79-82 — 2011 Mar 27 — 79-82

Tan L, Testa G, Yung T

Diffuse alveolar damage in BCGosis: a rare complication of intravesical bacillus Calmette-Guérin therapy for transitional cell carcinoma.

Pathology 1999 Feb;31;55-6 — 1999 Feb — 55-6

Paterson DL, Patel A

Bacillus Calmette-Guerin (BCG) immunotherapy for bladder cancer: review of complications and their treatment.

The Australian and New Zealand journal of surgery 1998 May;68;340-4 — 1998 May — 340-4