The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IV.k

Bronchiectasis

A recently (2010s) described pattern in transplant recipients

Publications

Dury S, Colosio C, Etienne I, Anglicheau D, Merieau E, Caillard S, Rivalan J, Thervet E, Essig M, Babinet F, Subra JF, Toubas O, Rieu P, Launois C, Perotin-Collard JM, Lebargy F, Deslée G, Spiesser group

Bronchiectasis diagnosed after renal transplantation: a retrospective multicenter study.

BMC pulmonary medicine. 2015;15:141

Boddana P, Webb LH, Unsworth J, Brealey M, Bingham C, Harper SJ

Hypogammaglobulinemia and bronchiectasis in mycophenolate mofetil-treated renal transplant recipients: an emerging clinical phenomenon?

Clinical transplantation. 2011;25(3):417-9

Merkus PJ, Pijnenburg M, Cransberg K

Mycophenolate mofetil and bronchiectasis in pediatric transplant patients.

Transplantation. 2006;82(10):1386

Rook M, Postma DS, van der Jagt EJ, van Minnen CA, van der Heide JJ, Ploeg RJ, van Son WJ

Mycophenolate mofetil and bronchiectasis in kidney transplant patients: a possible relationship.

Transplantation. 2006;81(2):287-9

Cransberg K, Marlies Cornelissen EA, Davin JC, Van Hoeck KJ, Lilien MR, Stijnen T, Nauta J

Improved outcome of pediatric kidney transplantations in the Netherlands -- effect of the introduction of mycophenolate mofetil?

Pediatric transplantation. 2005;9(1):104-11

Pijnenburg MW, Cransberg K, Wolff E, Bouquet J, Merkus PJ

Bronchiectasis in children after renal or liver transplantation: a report of five cases.

Pediatric transplantation. 2004;8(1):71-4