The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLIV.a

Angioedema (may cause UAO, asphyxia and death)

Publications

Diestro JDB, Sedano LSP, Reyes NGD, San Jose MCZ

Hemilingual Angioedema after Thrombolysis in a Patient on an Angiotensin II Receptor Blocker.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2019 May;28;e44-e45 — 2019 May — e44-e45

Strassen U, Bas M, Hoffmann TK, Knopf A, Greve J

Treatment of angiotensin receptor blocker-induced angioedema: A case series.

The Laryngoscope 2015 Jul;125;1619-23 — 2015 Jul — 1619-23

Montoro de Francisco A, García-Luque A, Fernández M, Puerro M

Side effects of angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists: are we facing a new syndrome.

The American journal of cardiology 2012 Nov 15;110;1552-3 — 2012 Nov 15 — 1552-3

Orgaz-Molina J, Soriano-Hernández MI, Husein-Elahmed H, Arias-Santiago S

[Angioedema due to losartan].

Medicina clinica 2011 Sep 10;137;281-2 — 2011 Sep 10 — 281-2

Kazim SF, Shahid M

Losartan associated anaphylaxis and angioneurotic oedema.

JPMA. The Journal of the Pakistan Medical Association 2010 Aug;60;685-6 — 2010 Aug — 685-6

Abdi R, Dong VM, Lee CJ, Ntoso KA

Angiotensin II receptor blocker-associated angioedema: on the heels of ACE inhibitor angioedema.

Pharmacotherapy 2002 Sep;22;1173-5 — 2002 Sep — 1173-5

Chiu AG, Krowiak EJ, Deeb ZE

Angioedema associated with angiotensin II receptor antagonists: challenging our knowledge of angioedema and its etiology.

The Laryngoscope 2001 Oct;111;1729-31 — 2001 Oct — 1729-31

Warner KK, Visconti JA, Tschampel MM

Angiotensin II receptor blockers in patients with ACE inhibitor-induced angioedema.

The Annals of pharmacotherapy 2000 Apr;34;526-8 — 2000 Apr — 526-8

Pylypchuk GB

ACE inhibitor- versus angiotensin II blocker-induced cough and angioedema.

The Annals of pharmacotherapy 1998 Oct;32;1060-6 — 1998 Oct — 1060-6

Acker CG, Greenberg A

Angioedema induced by the angiotensin II blocker losartan.

The New England journal of medicine 1995 Dec 07;333;1572 — 1995 Dec 07 — 1572