The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

VIII.a

Angioedema (may cause UAO, asphyxia and death)

Publications

Diestro JDB, Sedano LSP, Reyes NGD, San Jose MCZ

Hemilingual Angioedema after Thrombolysis in a Patient on an Angiotensin II Receptor Blocker.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 2019;28(5):e44-e45

Strassen U, Bas M, Hoffmann TK, Knopf A, Greve J

Treatment of angiotensin receptor blocker-induced angioedema: A case series.

The Laryngoscope. 2015;125(7):1619-23

Montoro de Francisco A, García-Luque A, Fernández M, Puerro M

Side effects of angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists: are we facing a new syndrome.

The American journal of cardiology. 2012;110(10):1552-3

Orgaz-Molina J, Soriano-Hernández MI, Husein-Elahmed H, Arias-Santiago S

[Angioedema due to losartan].

Medicina clinica. 2011;137(6):281-2

Kazim SF, Shahid M

Losartan associated anaphylaxis and angioneurotic oedema.

JPMA. The Journal of the Pakistan Medical Association. 2010;60(8):685-6

Abdi R, Dong VM, Lee CJ, Ntoso KA

Angiotensin II receptor blocker-associated angioedema: on the heels of ACE inhibitor angioedema.

Pharmacotherapy. 2002;22(9):1173-5

Chiu AG, Krowiak EJ, Deeb ZE

Angioedema associated with angiotensin II receptor antagonists: challenging our knowledge of angioedema and its etiology.

The Laryngoscope. 2001;111(10):1729-31

Warner KK, Visconti JA, Tschampel MM

Angiotensin II receptor blockers in patients with ACE inhibitor-induced angioedema.

The Annals of pharmacotherapy. 2000;34(4):526-8

Pylypchuk GB

ACE inhibitor- versus angiotensin II blocker-induced cough and angioedema.

The Annals of pharmacotherapy. 1998;32(10):1060-6

Acker CG, Greenberg A

Angioedema induced by the angiotensin II blocker losartan.

The New England journal of medicine. 1995;333(23):1572