The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

VIII.a

Angioedema (may cause UAO, asphyxia and death)

Publications

Jackeviciute J, Pilvinis V, Pilviniene R

Fatal outcome of late-onset angiotensin-converting enzyme inhibitor induced angioedema: A case report.

Medicine. 2018;97(31):e11695

Alencar RC, Cobas RA, Gomes MB

Allergic reaction related to ramipril use: a case report.

Diabetology & metabolic syndrome. 2010;2:4

ONTARGET Investigators, Yusuf S, Teo KK, Pogue J, Dyal L, Copland I, Schumacher H, Dagenais G, Sleight P, Anderson C

Telmisartan, ramipril, or both in patients at high risk for vascular events.

The New England journal of medicine. 2008;358(15):1547-59

Nielsen EW, Gramstad S

Angioedema from angiotensin-converting enzyme (ACE) inhibitor treated with complement 1 (C1) inhibitor concentrate.

Acta anaesthesiologica Scandinavica. 2006;50(1):120-2

Warrier MR, Copilevitz CA, Dykewicz MS, Slavin RG

Fresh frozen plasma in the treatment of resistant angiotensin-converting enzyme inhibitor angioedema.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 2004;92(5):573-5

Satkiene D, Kavoliūniene A, Petrauskiene I, Sirvyte R

[Tongue angioedema associated with angiotensin-converting enzyme inhibitor (diagnosis, differential diagnosis, treatment)].

Medicina (Kaunas, Lithuania). 2003;39(6):570-3

Messerli FH, Nussberger J

Vasopeptidase inhibition and angio-oedema.

Lancet (London, England). 2000;356(9230):608-9