The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.i

Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)

Publications

Siehr S, Stuth E, Tweddell J, Hoffman G, Troshynski T, Jones D, Mitchell M, Ghanayem N

Hypersensitivity reactions to aprotinin re-exposure in paediatric surgery.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2010 Feb;37;307-11 — 2010 Feb — 307-11