The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Angioedema (may cause UAO, asphyxia and death)
Publications
Images in clinical medicine. Angioedema of the tongue.
The New England journal of medicine. 2006;355(3):295
Simultaneous mucosal and small bowel angioedema due to captopril.
Southern medical journal. 1998;91(11):1060-3
Captopril-induced angioedema.
Annals of emergency medicine. 1984;13(6):489-90
Angioneurotic edema, agranulocytosis, and fatal septicemia following captopril therapy.
The American journal of medicine. 1986;81(2):336-8
Fatal angioedema associated with captopril.
Journal of forensic sciences. 1992;37(5):1418-21