The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLIV.a

Angioedema (may cause UAO, asphyxia and death)

Publications

Kent N, Allikesam KK, Ly A, Veerasammy M, Avula SK

A Rare Case of Idiopathic Angioedema Associated With Amlodipine Use.

Cureus 2025 Jul;17;e87661 — 2025 Jul — e87661

Hom KA, Hirsch R, Elluru RG

Antihypertensive drug-induced angioedema causing upper airway obstruction in children.

International journal of pediatric otorhinolaryngology 2012 Jan;76;14-9 — 2012 Jan — 14-9